The Book Quests and Zeke Quests are different from the rest. While most quests will "Open" an area when you are supposed to go there, these do not. You should try to get these quests right away when you get to a new world and then look at them ever so often when you open a new area and see if there is anything there that you need to find. Mainly I just get the quest when I first arrive in a new world and then by the time I'm done with that world the quest is complete. If I have not completed the quest yet then when I go back to get each item the area will be open so that I can get in. Hope this helps.