Of course! On the system requirements page of W101, it says that OS has to be Windows XP or higher, or Mac OS 10.6 (Snow Leopard) or higher. As long as you have the 512 MB of RAM, you'll be fine!
Yeah you can but it sucks! Windows 10 screwed up our whole computer. Now it has to delete our stuff and update a lot. Also on top of that wizard101 deletes itself every couple times when I log in to the computer. So in summary, you can play wizard101 but I don't recommend it(unless that's your only option)